It requires a well-updated Graphic card as well. Tried disabling them one by one and cant seem to find the problem. On PC, only 254 max plugins are allowed for Fallout 4 gameplay functionality without crashing. This can also be fixed using this method. Once I start a fresh game I can, strangely enough, play just fine without any issues and any crash.
EDIT: If the Mods option on the main menu of Fallout 4 doesn't appear in your game, make sure you update your copy. Answer (1 of 4): I can’t speak for the Xbox One, but I have no issues with Fallout 4 on the PS4.
Over there is a details anti-cash mod for Fallout new Vegas. As expected, the game maker released some patches to end the malfunction.
Disable any mods added and start a "new" save to see if the issue occurs on a brand new game. If it does not crash on a new game, the issue most likely is related to a bad save and/or mod. Fallout 4 CTD (crash on desktop) Fallout 4 Crash on Xbox One: This case is different from the above three cases.
How to fix Fallout 4 Game Crashes on Startup Fallout 4 has, for 10 months, refused to start up.